Post-Acute Sequelae of SARS-CoV-2 Infection and Its Impact on Adolescents and Young Adults.

Observed Findings

• Varying definitions of PASC exist across studies, complicating comparison and clinical recognition in adolescent and young adult populations
• Symptom profiles in younger patients differ from adults, with distinct patterns of fatigue, cognitive dysfunction, and activity intolerance
• Currently available assessment and management strategies remain largely supportive and symptom-focused
• Significant equity gaps exist in diagnosis and care of AYAs with suspected PASC, particularly affecting minority and underserved populations
• PASC substantially impacts educational achievement, employment, and psychosocial functioning in affected youth

Inferred Conclusions

• Standardized diagnostic criteria and definitions for PASC in adolescents and young adults are needed to improve clinical recognition and research comparability
• Multidisciplinary, patient-centered approaches that address physical, cognitive, and psychological impacts are essential for supporting affected youth
• Healthcare systems must address equity barriers to ensure all young people with PASC receive timely, appropriate care regardless of socioeconomic status or background
• Further research on long-term outcomes and mechanistic understanding of PASC in younger populations is critical for developing evidence-based treatments

Remaining Questions