Ewig, S · Deutsche medizinische Wochenschrift (1946) · 1993 · DOI
This is a review article about chronic fatigue syndrome (ME/CFS) published in a German medical journal. The author summarizes existing knowledge about the condition to help doctors and patients understand what was known about this illness in the early 1990s.
This article is a historical marker of how ME/CFS was understood and discussed in medical communities during the early 1990s. For patients and researchers, it provides perspective on how medical knowledge about this condition has evolved over the past 30+ years.
As a narrative review rather than original research, this article cannot establish causation, validate specific diagnostic tests, or provide new clinical data. It reflects only the state of knowledge available at that time and does not represent current understanding of ME/CFS mechanisms or treatment.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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