Ganesh, Ravindra, Vanichkachorn, Greg S, Munipalli, Bala et al. · Mayo Clinic proceedings. Innovations, quality & outcomes · 2022 · DOI
This study describes how Mayo Clinic, a large healthcare system across five states, created a coordinated plan to help patients recover from long-term COVID-19 symptoms. Doctors from many different specialties worked together to develop consistent guidelines for evaluating and treating these patients. The system includes specialized appointment forms, sample collection for research, and dedicated treatment programs to provide better care.
While focused on post-COVID patients, this study demonstrates how healthcare systems can organize multidisciplinary care for complex post-viral conditions with persistent fatigue and functional impairment. The consensus framework and implementation strategies may be adapted for ME/CFS clinical management and research infrastructure. The emphasis on standardized data collection and biobanking provides a model for improving research efficiency in post-infectious syndromes.
This consensus guideline does not prove the clinical effectiveness of any specific PASC treatment or diagnostic approach. It does not establish causal mechanisms for post-COVID symptoms or directly compare outcomes between different management strategies. The organizational framework itself has not been validated against alternative care models in controlled clinical trials.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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