Gantz, N M, Holmes, G P · Drugs · 1989 · DOI
This 1989 review article examines different ways doctors were treating ME/CFS patients at that time. The authors looked at what treatments were being used and discussed their potential benefits and drawbacks. This early work helped shape how doctors approached ME/CFS care in the following decades.
This early clinical perspective from recognized ME/CFS researchers helped establish foundational treatment discussions during a critical period when ME/CFS was gaining medical recognition. It represents important documentation of clinical approaches from the initial years of modern ME/CFS medicine, providing historical context for how treatment understanding has evolved.
As a review article from 1989, this work does not provide evidence from controlled clinical trials or experimental data to prove the effectiveness of any specific treatment. It reflects clinical opinions and practices of that era, which may not align with current medical understanding or evidence standards. The study cannot establish which treatments are definitively superior or which have the strongest evidence base.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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