Iasiukiavichene, L, Vasiliauskas, D · Kardiologiia · 2006
This review examines why people with heart disease often experience severe fatigue and how the body's stress response system may be involved. The authors explain that chronic fatigue is a condition affecting the immune system, hormones, and nervous system, and can be triggered by stress, surgery, infections, or other illnesses. They suggest that measuring a stress hormone called cortisol could help doctors identify and treat fatigue in heart patients.
This study is relevant to ME/CFS because it identifies HPA axis dysfunction and immune abnormalities as core mechanisms in severe chronic fatigue—findings that parallel ME/CFS research. Understanding how fatigue develops in cardiac patients may illuminate similar pathways in ME/CFS and support the case for measuring hormonal and immune markers in fatigue disorders.
This review does not establish that all chronic fatigue cases have identical mechanisms or that cortisol measurement alone can diagnose chronic fatigue or ME/CFS. The authors do not provide primary data demonstrating causation between HPA axis dysfunction and fatigue development, nor do they distinguish between fatigue secondary to cardiac disease and primary ME/CFS.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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