ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature
Anthony L. Komaroff, W. Ian Lipkin · Frontiers in Medicine · 2023 · DOI
Quick Summary
Harvard and Columbia researchers conducted a comprehensive review of biological abnormalities in ME/CFS and Long COVID. They found striking overlaps in immune dysregulation, autonomic dysfunction, metabolic disruption, and neurological features. The paper maps the literature to guide researchers working across both conditions.
Why It Matters
This review by two leading scientists provides a clear synthesis of convergent biological evidence across ME/CFS and Long COVID, supporting the idea that Long COVID is triggering ME/CFS-like disease and that ME/CFS research is highly relevant to understanding Long COVID.
What This Study Does Not Prove
A narrative review cannot establish causation. The overlap in symptoms does not prove identical pathophysiology.
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Metadata
- DOI
- 10.3389/fmed.2023.1187163
- Review status
- Editor reviewed
- Evidence level
- Established evidence from major reviews, guidelines, or evidence maps
- Last updated
- 7 April 2026