Landis, Carol A · Handbook of clinical neurology · 2011 · DOI
This review examined the connections between sleep problems, pain, fibromyalgia, and chronic fatigue syndrome (ME/CFS). The author looked at existing research to understand how poor sleep and pain symptoms often occur together in these conditions and how they may be related to each other.
Understanding how sleep problems and pain interconnect in ME/CFS is crucial because addressing sleep dysfunction may help manage pain symptoms and vice versa. This review helps patients and clinicians recognize that these symptoms are not separate problems but part of an interconnected system, potentially opening new treatment avenues.
This review does not prove that sleep problems cause pain in ME/CFS or establish definitive causal mechanisms. It also does not provide new experimental data and relies on existing literature, so the conclusions are only as strong as the underlying studies reviewed.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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