E3 PreliminaryPreliminaryPEM ?Case-ControlPeer-reviewedMachine draft
Orthostatic intolerance as a potential contributor to prolonged fatigue and inconsistent performance in elite swimmers.
Petracek, Lindsay S, Eastin, Ella F, Rowe, Ian R et al. · BMC sports science, medicine & rehabilitation · 2022 · DOI
Quick Summary
This study looked at five elite swimmers who experienced severe fatigue and couldn't perform at their usual level. The researchers tested whether orthostatic intolerance—a condition where the body struggles to maintain proper blood pressure when standing—might explain their symptoms. When the swimmers were tested with standing or tilt table tests, they all felt fatigued and other symptoms appeared. After receiving treatment with extra salt and fluids, all five swimmers felt significantly better and returned to normal performance.
Why It Matters
Many ME/CFS patients experience orthostatic intolerance and profound fatigue, similar to the swimmers in this study. This research demonstrates that orthostatic intolerance is measurable through accessible clinical tests and can be effectively treated with simple interventions. Identifying and addressing orthostatic intolerance may help ME/CFS patients and other fatigued patients improve their functioning and quality of life.
Observed Findings
- All five elite swimmers with fatigue and underperformance showed symptoms when subjected to orthostatic testing (passive standing or tilt table).
- Two of the five swimmers met heart rate criteria for postural tachycardia syndrome (POTS).
- All five swimmers experienced prompt improvement in fatigue and orthostatic symptoms after treatment with increased sodium chloride and fluid intake.
- All five swimmers were able to return to their expected performance level or improve their practice consistency following treatment.
- Orthostatic testing reliably provoked fatigue and other symptoms in all participants.
Inferred Conclusions
- Orthostatic intolerance is an easily measured and treatable contributor to athletic underperformance in at least some athletes with fatigue.
- Formal orthostatic testing (passive standing tests or tilt table tests) should be incorporated into clinical evaluation of athletes presenting with fatigue and underperformance.
- Simple interventions targeting orthostasis (sodium and fluid replacement) may provide significant functional improvement in some underperforming athletes.
- Orthostatic intolerance should be considered alongside other potential causes such as overtraining syndrome and ME/CFS when evaluating athletes with persistent fatigue.
Remaining Questions
What This Study Does Not Prove
This small case series (n=5) cannot establish that orthostatic intolerance is the primary cause of athlete underperformance, only that it was present and treatable in these specific individuals. The lack of a control group means we cannot determine how common orthostatic intolerance is in underperforming athletes generally. Results in elite swimmers may not generalize to other populations or to the broader ME/CFS patient population.
Tags
Symptom:Orthostatic IntoleranceFatigue
Biomarker:Blood Biomarker
Phenotype:Pediatric
Method Flag:Weak Case DefinitionNo ControlsSmall SampleExploratory Only