E1 ReplicatedModerate confidencePEM not requiredRCTPeer-reviewedMachine draft
A controlled study of the effect of a mindfulness-based stress reduction technique in women with multiple chemical sensitivity, chronic fatigue syndrome, and fibromyalgia.
Sampalli, Tara, Berlasso, Elizabeth, Fox, Roy et al. · Journal of multidisciplinary healthcare · 2009 · DOI
Quick Summary
This study tested whether a 10-week mindfulness and stress reduction program could help women with ME/CFS, fibromyalgia, and chemical sensitivities. Compared to women on a waiting list, those who completed the program showed significant improvements in psychological distress symptoms both immediately after and three months later. The results suggest that mindfulness-based techniques may be a helpful complementary approach for managing these chronic conditions.
Why It Matters
This study provides evidence that psychological stress reduction techniques may help reduce symptom burden in ME/CFS patients. Since psychological distress often accompanies ME/CFS and may worsen symptoms, identifying complementary interventions that safely reduce distress without requiring physical exertion is clinically relevant for patient care and quality of life.
Observed Findings
- Global psychological distress scores improved significantly in the MBSR group from pre- to post-intervention (p<0.0001) and from pre- to 3-month follow-up (p<0.0001).
- Control group global scores showed no significant change over the same period.
- 5 of 9 SCL-90R subscales showed statistically significant improvement in the MBSR group post-intervention.
- 8 of 9 SCL-90R subscales showed statistically significant improvement in the MBSR group at 3-month follow-up.
- Improvements were sustained or further improved from post-intervention to follow-up in the treatment group.
Inferred Conclusions
- Mindfulness-based stress reduction is an effective complementary intervention for reducing psychological distress in women with ME/CFS, fibromyalgia, and multiple chemical sensitivity.
- The benefits of MBSR persist at least three months following program completion.
- Psychological interventions may play an important role in the symptom management strategy for these chronic conditions.
Remaining Questions
- Does reduction in psychological distress translate to improvement in core ME/CFS symptoms such as post-exertional malaise, cognitive dysfunction, or sleep disturbance?
- Does MBSR work equally well for patients with different disease severities, particularly those who are housebound or bedbound?
What This Study Does Not Prove
This study does not prove that mindfulness treats the underlying biological dysfunction of ME/CFS itself—it only demonstrates reduction in psychological distress symptoms. The study does not establish whether improvements in psychological measures correlate with improvements in physical fatigue, post-exertional malaise, or other core ME/CFS symptoms. The reliance on self-reported psychological distress measures means results may reflect changes in mood perception rather than objective disease improvement.
Tags
Symptom:PainFatigue
Method Flag:PEM Not DefinedWeak Case DefinitionExploratory OnlyMixed Cohort
Metadata
- DOI
- 10.2147/jmdh.s5220
- PMID
- 21197347
- Review status
- Machine draft
- Evidence level
- Replicated human evidence from multiple independent studies
- Last updated
- 8 April 2026
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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