CFSMEATLAS — The Atlas of ME/CFS

135 studies

Showing 81–100 of 135 studies

E3 PreliminaryPEM ✓Moderate confidenceEditorialReviewed

[Post-COVID syndrome with fatigue and exercise intolerance: myalgic encephalomyelitis/chronic fatigue syndrome].

Renz-Polster, Herbert, Scheibenbogen, Carmen·Innere Medizin (Heidelberg, Germany)·2022

This article explains that ME/CFS is a serious neurological and immune system disease, often triggered by infections like COVID-19, characterized by extreme fatigue lasting at least 6 months and a unique symptom called post-exertional malaise (PEM)—where even mild activity causes symptoms to worsen hours or days later. The authors stress that ME/CFS is a distinct medical condition that should not be confused with ordinary tiredness, and while there is no cure yet, treatment focuses on managing symptoms, addressing related circulation problems, and helping patients conserve energy through pacing.

Post-Exertional Malaise

E0 ConsensusPEM ✓Moderate confidenceSystematic-ReviewReviewed

The evidence base for physiotherapy in myalgic encephalomyelitis/chronic fatigue syndrome when considering post-exertional malaise: a systematic review and narrative synthesis.

Wormgoor, Marjon E A, Rodenburg, Sanne C·Journal of translational medicine·2021

This review looked at 18 studies testing physiotherapy (physical therapy) for ME/CFS, paying special attention to post-exertional malaise (PEM)—the worsening of symptoms after activity that defines ME. The researchers found that treatments appearing to help patients with general chronic fatigue showed less benefit when studied in patients with stricter ME/CFS definitions that include PEM, and may actually cause harm in ME patients. The study warns that physical therapy approaches effective for milder conditions should not be used for ME patients with prominent PEM.

Post-Exertional Malaise

E0 ConsensusPEM ✓Moderate confidenceReview-NarrativeMachine draft

The Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Current Evidence and Potential Therapeutic Applications.

Varesi, Angelica, Deumer, Undine-Sophie, Ananth, Sanjana et al.·Journal of clinical medicine·2021

Many people with ME/CFS experience stomach and digestive problems alongside their fatigue and pain. This review explores how the bacteria living in our gut might be different in ME/CFS patients and could be contributing to symptoms. The researchers found that people with ME/CFS tend to have fewer types of gut bacteria compared to healthy people, and they discuss how treating the gut microbiome might help reduce ME/CFS symptoms overall.

Post-Exertional Malaise

E0 ConsensusPEM ✓PreliminarySystematic-ReviewReviewed

Systematic Review of Mind-Body Interventions to Treat Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Khanpour Ardestani, Samaneh, Karkhaneh, Mohammad, Stein, Eleanor et al.·Medicina (Kaunas, Lithuania)·2021

Researchers looked at 12 studies examining whether mind-body techniques like meditation, yoga, and relaxation exercises could help ME/CFS symptoms. Most studies found these techniques improved fatigue, anxiety, and depression, and helped people feel better overall. However, the studies were small and used different methods, so we need more research to know how well these treatments really work.

E3 PreliminaryPEM ✓Moderate confidenceReview-NarrativeReviewed

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview.

Deumer, Undine-Sophie, Varesi, Angelica, Floris, Valentina et al.·Journal of clinical medicine·2021

ME/CFS is a long-term illness that causes extreme tiredness, worsening of symptoms after activity, and difficulty thinking clearly. Patients experience these symptoms very differently from one another, and currently there are no blood tests or physical exams that can definitively diagnose the condition. This review examines several potential causes, including past infections, genetic factors, hormone imbalances, and changes in gut bacteria, while exploring whether a simple blood test might someday help diagnose ME/CFS.

Biomarkers Post-Exertional Malaise

E0 ConsensusPEM ?Moderate confidenceReview-NarrativeReviewed

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from?

Toogood, Peter L, Clauw, Daniel J, Phadke, Sameer et al.·Pharmacological research·2021

ME/CFS is a serious illness causing extreme fatigue that doesn't improve with rest, along with pain, sleep problems, and difficulty thinking clearly. This review looks at what we currently know about ME/CFS, how doctors diagnose it, and what treatments exist today. The authors examined past research to identify promising targets for new medicines that could help treat ME/CFS in the future.

Post-Exertional Malaise Immune Dysregulation

E0 ConsensusPEM ✓Higher confidenceGuidelineReviewed

Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management

NICE Guideline Committee·National Institute for Health and Care Excellence (NICE)·2021

The UK's National Institute for Health and Care Excellence updated its ME/CFS guidelines after a comprehensive evidence review. The updated guidelines removed Graded Exercise Therapy (GET) and Cognitive Behavioural Therapy (CBT) as recommended treatments, as evidence showed they were not effective and could be harmful. Pacing and energy management were endorsed.

Interventions Diagnostics

E0 ConsensusPEM ?Moderate confidenceReview-NarrativeMachine draft

Insights into Metabolite Diagnostic Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Yamano, Emi, Watanabe, Yasuyoshi, Kataoka, Yosky·International journal of molecular sciences·2021

ME/CFS is a serious condition that causes extreme exhaustion and is difficult to diagnose because we don't have reliable tests for it. This review examined research on how the chemicals in patients' bodies differ from healthy people, looking for patterns that could help doctors identify ME/CFS with a simple blood test. Scientists reviewed studies that measured these body chemicals and tested them in animal models to understand what goes wrong in ME/CFS.

Biomarkers

E3 PreliminaryPEM ?Weak / uncertainEditorialMachine draft

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: When Suffering Is Multiplied.

Komaroff, Anthony L·Healthcare (Basel, Switzerland)·2021

ME/CFS is a real illness with measurable biological problems in the body, even though standard blood tests often appear normal. Over the past 20 years, advanced research tools have found objective abnormalities in people with ME/CFS. Unfortunately, many doctors aren't aware of this evidence, which can lead them to dismiss patients' symptoms and wrongly suggest there's nothing physically wrong—adding emotional harm on top of the already serious illness.

Biomarkers

E0 ConsensusPEM ✓Moderate confidenceReview-NarrativeMachine draft

Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome.

Paul, Bindu D, Lemle, Marian D, Komaroff, Anthony L et al.·Proceedings of the National Academy of Sciences of the United States of America·2021

This review examines how COVID-19 and ME/CFS may share similar biological problems, particularly an imbalance in how the body handles harmful molecules called free radicals. Both conditions appear to involve problems with inflammation, energy production in cells, and a slowed metabolism. While this research shows these biological abnormalities exist in both illnesses, more studies are needed to understand exactly how they work together and how to treat them.

Neuroinflammation Post-Exertional Malaise

E3 PreliminaryPEM ?Moderate confidenceGuidelineReviewed

European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe.

Nacul, Luis, Authier, François Jérôme, Scheibenbogen, Carmen et al.·Medicina (Kaunas, Lithuania)·2021

This study brings together ME/CFS experts from 22 European countries to agree on how to diagnose the illness and provide better care for patients. The researchers and healthcare professionals worked together with people who have ME/CFS to create recommendations that can help doctors recognize and treat the condition more consistently across Europe. Their goal was to improve diagnosis and healthcare services for ME/CFS patients everywhere.

E2 ModeratePEM ?PreliminaryObservationalReviewed

Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole.

Crosby, L D, Kalanidhi, S, Bonilla, A et al.·Journal of translational medicine·2021

This study looked back at medical records of 101 ME/CFS patients who were prescribed a low dose of aripiprazole, a medication typically used for other conditions. The researchers found that some patients reported improvements in their symptoms. While these results are encouraging, the study design means we need to be cautious about how much weight to give these findings.

E0 ConsensusPEM ?Moderate confidenceEditorialReviewed

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back!

Ariza, Maria Eugenia·Biomolecules·2021

This review examines whether certain viruses, particularly Epstein-Barr virus (EBV), may play a role in ME/CFS. Earlier research on this topic produced mixed results, leading some scientists to think viruses weren't involved. However, newer research methods have found that specific proteins made by EBV could contribute to immune system and nervous system problems in some ME/CFS patients.

Biomarkers Immune Dysregulation

E0 ConsensusPEM ?PreliminarySystematic-ReviewReviewed

Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systemic Review and Comparison of Clinical Presentation and Symptomatology.

Wong, Timothy L, Weitzer, Danielle J·Medicina (Kaunas, Lithuania)·2021

Researchers reviewed 21 studies about Long COVID (symptoms lasting months after COVID-19 infection) and compared them to ME/CFS symptoms. They found that Long COVID patients reported 25 out of 29 known ME/CFS symptoms, suggesting these two conditions share many similarities. The study highlights the need for better monitoring and treatment of patients with Long COVID, and calls for more standardized research methods to understand both conditions better.

E3 PreliminaryPEM ✓PreliminaryReview-NarrativeReviewed

COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review.

Poenaru, Sonia, Abdallah, Sara J, Corrales-Medina, Vicente et al.·Therapeutic advances in infectious disease·2021

Some people who recover from COVID-19 continue experiencing prolonged symptoms like fatigue, difficulty breathing, and brain fog for months afterward. These lingering symptoms are remarkably similar to ME/CFS, a chronic illness characterized by severe fatigue that worsens with activity. While COVID-19 could potentially trigger ME/CFS in some people, researchers currently don't have enough evidence to confirm this connection.

Post-Exertional Malaise Severe ME

E0 ConsensusPEM ✓Higher confidenceMeta-AnalysisReviewed

Meta-analysis investigating post-exertional malaise between patients and controls.

Brown, Abigail, Jason, Leonard A·Journal of health psychology·2020

This study looked at research from multiple studies to understand how common post-exertional malaise (PEM) is in people with ME/CFS. Post-exertional malaise is when symptoms get worse after physical or mental activity. The researchers found that people with ME/CFS are about 10 times more likely to experience post-exertional malaise than people without the condition, suggesting it is a key feature of ME/CFS.

Post-Exertional Malaise

E3 PreliminaryPEM ?PreliminaryCase-ControlMachine draft

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Efficacy of Repeat Immunoadsorption.

Tölle, Markus, Freitag, Helma, Antelmann, Michaela et al.·Journal of clinical medicine·2020

This study tested a blood-cleaning treatment called immunoadsorption (IA) on five ME/CFS patients who had previously improved with this therapy. About two years later, they received the treatment again using a slightly modified approach. Four of the five patients showed improvement in their symptoms that lasted 6-12 months, and the treatment was well tolerated with no serious side effects.

Immune Dysregulation

E0 ConsensusPEM ?Weak / uncertainSystematic-ReviewReviewed

A systematic review of metabolomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID).

Huth, Teilah Kathryn, Eaton-Fitch, Natalie, Staines, Donald et al.·Journal of translational medicine·2020

Researchers reviewed 11 studies that measured tiny chemical molecules (metabolites) in the blood and urine of ME/CFS patients to see if problems with these chemicals might explain the illness. While they found some patterns—especially with chemicals related to amino acids (building blocks of proteins)—the results were inconsistent across different studies. The researchers concluded that we don't yet have enough evidence that metabolite problems cause ME/CFS.

Biomarkers

E0 ConsensusPEM ✓Higher confidenceSystematic-ReviewReviewed

Review of case definitions for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Lim, Eun-Jin, Son, Chang-Gue·Journal of translational medicine·2020

This study reviewed how ME/CFS has been defined and diagnosed over the past 34 years, examining 25 different case definitions created by researchers. The researchers found that these definitions fall into four main categories and emphasize different key symptoms—some focus on a viral cause, others on inflammation, and some on multiple system problems. Understanding these different approaches helps doctors and patients recognize that ME/CFS is complex and may require more than one way to diagnose it.

Cognitive Impairment Post-Exertional Malaise

E3 PreliminaryPEM ?PreliminaryCase-ControlReviewed

Severe ME in Children.

Speight, Nigel·Healthcare (Basel, Switzerland)·2020

This study looks at severe ME/CFS in children who are so sick they can barely leave their homes or beds. The doctor who wrote it shares real patient stories to show how the illness presents and how to manage it properly. The study highlights an important problem: many doctors don't recognize or diagnose ME/CFS, and there's very little information available about the most severely affected patients.

Severe ME

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Evidence Atlas

Evidence Atlas

The research, structured.

[Post-COVID syndrome with fatigue and exercise intolerance: myalgic encephalomyelitis/chronic fatigue syndrome].

The evidence base for physiotherapy in myalgic encephalomyelitis/chronic fatigue syndrome when considering post-exertional malaise: a systematic review and narrative synthesis.

The Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Current Evidence and Potential Therapeutic Applications.

Systematic Review of Mind-Body Interventions to Treat Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from?

Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management

Insights into Metabolite Diagnostic Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: When Suffering Is Multiplied.

Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome.

European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe.

Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back!

Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systemic Review and Comparison of Clinical Presentation and Symptomatology.

COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review.

Meta-analysis investigating post-exertional malaise between patients and controls.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Efficacy of Repeat Immunoadsorption.

A systematic review of metabolomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID).

Review of case definitions for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Severe ME in Children.

Research Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research